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Lymph node (Hematopathology):   Click on section headings below (in blue) to expand or collapse the section content

Most Commonly Rendered Diagnoses


This section is a synoptic list of diagnostic wordings for the most commonly rendered diagnoses in this organ / system. For details and more, go to the specific category sections below.


General / Common Abnormalities of  the Lymph Nodes:     

-- Reactive follicular and paracortical hyperplasia.

-- Benign reactive lymph nodes with follicular hyperplasia and progressive transformation of germinal center.

-- Dermatopathic lymphadenopathy

-- Diffuse large B-cell lymphoma with high proliferation rate (90% positive for Ki67) (Microscopic Description & Lab Work-Up ).

-- _______ lymphoma, grade _______ (see Microscopic Description & Lab Work-up)


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Non-Hodgkins Lymphomas

Hodgkins Lymphomas

Plasmacytic Neoplasm

Non-Neoplastic Lymphadenopathy



Microscopic Description and Lab Work-Up
Histologic sections show diffuse infiltration of the tissue by intermediate-large lymphocytes with pleomorphic nuclei, one to several prominent nucleoli and frequent mitotic figures.   The malignant cells are admixed with a small number of small lymphocytes with mature cytological features.  Many macrophages with ingested apoptotic tumor cells are found throughout the sections, imparting a "starry sky" pattern. Malignant cells are found at the marked deep margin. Touch preps show many pleomorphic intermediate-large cells, admixed with a small number of mature lymphocytes. The malignant cells have basophilic cytoplasm without cytoplasmic vacuoles.
Immunohistochemical stains performed on block 1C, with adequate controls, show that the malignant cells are positive for CD10, and CD20, but are negative for bcl-1, bcl-2, CD3, CD30, and ALK-1. Ki-67 shows a proliferation rate of about 90%.  EBV-LMP is negative.
Immunophenotyping by flow cytometry in gate#1 shows a predominant B-cell population (>90% of the cells analyzed) that is positive for CD10, CD19, CD20, CD22, and surface lambda light-chain restriction.  They are negative for CD5, and CD23. These B-cells have intermediate-large nuclear size (based on forward-scatter signal). Analysis in gate #2 shows a small T-cell population with no aberrant loss or aberrant expression of T-cell markers and a normal B-cells population.
(Diffuse Large B-cell Lymphoma)
Microscopic Description and Lab Work-Up
Histologic sections show diffuse infiltration of the tissue by intermediate-large lymphocytes with pleomorphic nuclei, one to several prominent nucleoli and frequent mitotic figures.   The malignant cells are admixed with a small number of small lymphocytes with mature cytological features.  Many macrophages with ingested apoptotic tumor cells are found throughout the sections, imparting a "starry sky" pattern. Malignant cells are found at the marked deep margin. Touch preps show many pleomorphic intermediate-large cells, admixed with a small number of mature lymphocytes. The malignant cells have basophilic cytoplasm without cytoplasmic vacuoles.
Immunohistochemical stains performed on block 1C, with adequate controls, show that the malignant cells are positive for CD10, and CD20, but are negative for bcl-1, bcl-2, CD3, CD30, and ALK-1. Ki-67 shows a proliferation rate of about 90%.  EBV-LMP is negative.
Immunophenotyping by flow cytometry in gate#1 shows a predominant B-cell population (>90% of the cells analyzed) that is positive for CD10, CD19, CD20, CD22, and surface lambda light-chain restriction.  They are negative for CD5, and CD23. These B-cells have intermediate-large nuclear size (based on forward-scatter signal). Analysis in gate #2 shows a small T-cell population with no aberrant loss or aberrant expression of T-cell markers and a normal B-cells population.
(Diffuse Large B-cell Lymphoma)
Microscopic Description and Lab Work-Up
Key:  Features of both follicular lymphoma and diffuse large B-cell lymphoma.
Histology:  Diffuse infiltration by large neoplastic cells and poorly-defined follicles.
Immunostains:  Follicular cells positive for Bcl2, CD10. Diffuse large neoplastic cells positive CD30 and high Ki67 positivity rate.
Flowcytometry:  Large cells positive for CD19, CD20, CD22, and surface light-chain restriction, intermediate-large nuclear size (based on forward-scatter signal).

(Diffuse large B-cell lymphoma and follicular lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Large pleomorphic neoplastic cells; predominant small mature lymphocytes
Immunostain:  Positive for CD45, CD20, and PAX-5. Negative for myogenin, CD3, CD15, CD30, CD99, and ALK-1.
Flow-cytometry: Due to relative small proportion of the neoplastic cells, flow cytometry often show normal immunophenotype.  Thus, the flow cytometric results are often not diagnostic for T-cell/histiocyte-rich large B-cell lymphoma.

(T-cell/histiocyte-rich large B-cell lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)
Microscopic Description and Lab Work-Up
Histology:  Diffuse infiltration, vesicular nuclei with one to several nucleoli. Frequent mitotic figures.  "starry sky" pattern by numerous macrophages with ingested apoptotic debris.  Prominent nucleoli, basophilic cytoplasm with many vacuoles onTouch preps (diff-quik)
IHC stains: Positive for CD20, CD10, bcl-6, but  negative for CD5, bcl-1, and bcl-2. Ki67 (proliferation rate approaching 100%).
Immunophenotyping:  Predominant abnormal B cell population (> 90% of the lymphocytes gated); positive for CD19, CD20, CD22, CD10, FMC7, and surface lambda light chain restriction. Negative for CD5, and CD23. Predominantly intermediate cell (based on forward-scatter signal)
(Burkitt's Lymphoma)

Suckerfish Dropdowns - One Level Bones

Suckerfish Dropdowns - One Level Bones

Suckerfish Dropdowns - One Level Bones

Suckerfish Dropdowns - One Level Bones

Suckerfish Dropdowns - One Level Bones




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