Microscopic Description and Lab Work-Up

Key:  Features of both follicular lymphoma and diffuse large B-cell lymphoma.

Histology:  Diffuse infiltration by large neoplastic cells and poorly-defined follicles.

Immunostains:  Follicular cells positive for Bcl2, CD10. Diffuse large neoplastic cells positive CD30 and high Ki67 positivity rate.

Flowcytometry:  Large cells positive for CD19, CD20, CD22, and surface light-chain restriction, intermediate-large nuclear size (based on forward-scatter signal).

(Diffuse large B-cell lymphoma and follicular lymphoma)