 | About this Section The section introduces recently reported diagnostic entities. Check on the sources of report. |
The Entity | Sclerosing Epithelioid Mesenchymal Neoplasm of the Pancreas |
Clinical Features | -- Indolent neoplasm of the pancreas seen in adults -- Female:Male = 6 : 2 -- No metastasis has been reported |
Morphology | -- Well-circumscribed solid lesion with alternating cellular and fibrotic areas -- Poorly demarcated sheets of epithelioid cells with oval nucleus, coarse or stipple chromatin, occasional small nucleolus. -- Fibrotic/sclerotic area with tumor cells dispersed among thick collagen strands. -- Mitoses were rare, and no mucin production, -- Positive for AE1/3, CD99 and vimentin (all in 100% cases) -- No distinct molecular profile |
Main DDx. | Pancreatic ductal carcinoma: Sclerosing Epithelioid Fibrosarcomas Sarcomatoid Carcinomas of the Pancreas |
Reference | Basturk O, Weigelt B, et al. Mod Pathol. 2020;33(3):456–467. doi:10.1038/s41379-019-0334-5, Free Article |
Entity | Regenerative Hepatic Pseudotumor (RHP) |
Clinical Features | -- A benign reactive lesion -- Visible on imaging with no characteristics, 2 to 9 cm -- Female = Male, age 28 to 73 y |
Morphology | -- Grossly, vague but visible borders with adjacent normal liver -- Benign reactive liver parenchyma with central or portal vein thrombi. -- Sinusoidal dilation, patchy bile ductular proliferation, and portal vein abnormalities. |
Main DDx | Hepatic adenomas Focal nodular hyperplasia, |
Reference |