Bone & Joint

Bone & Joint

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Grade	Histologic Features
Grade 1 (low-grade)	Very similar to enchondroma; higher cellularity and mild cellular pleomorphism; small nuclei with open chromatin and small nucleoli; frequent binucleated cells; very rare mitoses. multinucleated giant cells may be seen.
Grade 2 (low-grade)	Higher cellularity than in Grade 1 tumors; Characteristically moderate cellular pleomorphism, plump nuclei, frequent bi-nucleated cells, and occasional bizarre cells; rare mitoses; foci of myxoid change.
Grade 3 (high-grade)	Characteristically hypercellular (high cellularity), marked cellular pleomorphism, high N/C ratio, many bizarre cells and frequent mitoses (more than 1 per hpf);