Grade

Histologic Features (DCIS)

Low

small monotonous nuclei; usually no/focal comedo-type necrosis; resembles lobular intraepithelial neoplasia; usually cribriform, micropapillary, papillary, solid. 0-10% progress to invasive disease.

Intermediate

between high grade and low grade

High

large, pleomorphic angular nuclei, frequent mitoses and prominent nucleoli; comedo-type necrosis nearly always present and often extensive. 40% progress to invasive disease.

*

Tubule Formation (% of carcinoma)

Score

   Tubule formation >75%

1

   Tubule formation 10-75%

2

   Tubule formation < 10%

3

Nuclear Pleomorphism

Score

   Small, uniform cells

1

   Moderate increase in size and variation

2

   Marked variation

3

Mitotic Count (per 10 high power fields)

Score

   Up to 7 mitotic figures / 10 HPF

1

   8 -14 mitotic figures / 10 HPF

2

   15 or more mitotic figures / 10 HPF

3

Grade

Score

Differentiation

5-year Survival

7-year Survival

1

3 to 5

Well

95 %

90 %

2

6 or 7

Moderately

75 %

65 %

3

8 or 9

Poorly

50 %

45 %