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Home --> Grading Schema (main page) --> Colorectum |
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Colorectum
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Glandular Dysplasia Associated with Inflammatory Bowel Diseases (IBD)
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Category |
Histologic Features |
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No dysplasia |
Well-preserved crypt architecture, basally located nuclei, uniform nuclear changes, plenty cytoplasmic mucin, inconspicuous nucleoli; no or minimal nuclear overlapping, hyperchromasia or enlargement. |
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Indefinite for dysplasia |
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Low-grade dysplasia |
Close resemblance to tubular adenomas (nuclear stratification in the lower half portion); mitotically active cells near the free surface. Relatively preserved crypt architecture |
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High-grade dysplasia * |
Close resemblance to tubular adenomas (but worse cytologic atypia); changes involves surface epithelium. Nuclear stratification beyond the mid portion. loss of nuclear uniformity (i.e. pleomorphism) and polarity (i.e. disarray); nuclear round-up, nuclear hyperchromasia, prominent nucleoli. |
*The category “high-grade dysplasia” includes carcinoma in situ.
* When low- and high-grade dysplasia co-exist, report severity of the dysplasia based on the worst changes present, not the prevailing ones. In this setting, high-grade dysplasia in three crypts or more is sufficient for the diagnosis.
Acute Graft Versus Host Disease (GVHD), Gastrointestinal
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