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Home --> Grading Schema (main page) --> Heart |
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Heart
(Click the section headings (in blue) to expand or collapse the content)
Cardiac Allograft Rejection|
Category |
Histologic Features |
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0 |
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1A |
Focal (perivascular or interstitial) infiltrate without necrosis |
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1B |
Diffuse but sparse infiltrate without necrosis |
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2 |
One focus only with aggressive infiltration and/or focal myocyte damage |
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3A |
Multifocal aggressive infiltrates and/or myocyte damage |
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3B |
Diffuse inflammatory process with necrosis |
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4 |
Diffuse aggressive polymorphous ± infiltrate ± edema, ± hemorrhage, ± vasculitis, with necrosis |
Additional Required Information* (Must be added to biopsy report if present)
-- Biopsy less than 4 pieces
-- Humoral rejection (positive IF, vasculitis, or severe edema in absence of cellular infiltrate
-- "Quilty" effect
A = No myocyte encroachment
B = With myocyte encroachment
-- Ischemia
A = Up to 3 weeks posttransplant
B = Late ischemia
-- Infection present - biopsy therefore uninterpretable
-- Lymphoproliferative disorder
-- Other (specify)
Revision of the 1990 Working Formulation for the Standardization of Nomenclature in the Diagnosis of Heart Rejection
The Journal of Heart and Lung Transplantation, Volume 24, Issue 11, November 2005, Pages 1710-1720
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